Methods of pathogen inactivation in whole blood and red blood cells: current state of knowledge

Although pathogen reduction technology was implemented for platelet concentrates and plasma, the risk of transmission has not been completely eliminated as no inactivation procedures were red blood cells whole blood. Research therefore focused on developing methods effective in cell components. Attempts made to apply either chemical compounds (porphyrins Sylsense compounds) or photosensitizers such methylene blue (Theraflex MB Plasma System) amotosalen hydrochloride (Intercept already use plasma. None proved cells. Approval recently given based S-303 compound (for cells) with riboflavin blood). Clinical trials are ongoing. Pilot studies have shown that during storage packed subjected demonstrated slight loss cells, decrease hemoglobin concentration, significantly lower lactate pH. Pathogen inactivated stored at room temperature up seven days showed hemolysis (within normal range). This paper presents several pilot clinical It focuses primarily recovery recipient's organism concentration.